Copper-promoted aerial oxidation of benzothiadiazines: access to benzothiadiazine S-oxide heterocycles.

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is necessary for the replication of viral RNA and thus represents an attractive target for drug development. Several structural classes of nonnucleoside inhibitors (NNIs) of HCV RNA polymerase have been described, including a promising series of benzothiadiazine compounds that efficiently block replication of HCV subgenomic replicons i...

Manganese Oxide Promoted LaCoO3 Nano-Perovskite for Oxidation of a Model Exhaust Gas

Application of copper oxide nanoparticles modified glassy carbon electrode for electrocatalytic oxidation of methanol

Copper nanoparticles were fabricated by electro-reduction of CuSO4solution in the presence of cetyltrimethylammonium bromide (CTAB) cationic surfactant as an additive through potentiostatic method. The prepared copper nanoparticles were characterized by scanning electron microscopy (SEM) and electrochemical methods. The SEM images reveal that the nanoparticles with diameters at about 70 n...

Catalytic Aerobic Dehydrogenation of Nitrogen Heterocycles Using Heterogeneous Cobalt Oxide Supported on Nitrogen-Doped Carbon.

Dehydrogenation of (partially) saturated heterocycles provides an important route to heteroaromatic compounds. A heterogeneous cobalt oxide catalyst, previously employed for aerobic oxidation of alcohols and amines, is shown to be effective for aerobic dehydrogenation of various 1,2,3,4-tetrahydroquinolines to the corresponding quinolines. The reactions proceed in good yields under mild conditi...

Antihypertensive action of benzothiadiazines.

C HLOROTHIAZIDE and other diuretics of similar structure have become established as valuable therapeutic agents in the control of hypertension. While not entirely free of toxicity, these drugs produce few disturbing side-effects. In addition, they have a relatively flat dose response curve in the therapeutic range. This permits fairly uniform dose schedules, which is an important feature of dru...